He frequently appears as characters who are deformed or inhuman, starting with his role as Amoukar in Guerre du feu, La (1981).
With a career spanning over three decades, Ron Perlman has worked alongside such diverse actors as Marlon Brando, Sean Connery, Cameron Diaz, Brad Dourif, Ed Harris, John Hurt, Jude Law, Christina Ricci, Wesley Snipes, Sigourney Weaver, Michael Wincott, and Elijah Wood to name a few.
He has played everything from a prehistoric tribesman to a good-hearted Colonel, and will always be a rarity in Hollywood.
His first real breakthrough came when he landed the role of Vincent, the lion-man, opposite Linda Hamilton in the cult-series Beauty and the Beast (1987). His work in this role earned him not only a Golden Globe Award, but a huge fan following.
While he has never been a bankable star, Ron Perlman has always had a large fan-base. He started out strong as Amoukar, one of the tribesmen in Jean-Jacques Annaud's Academy Award-winning film, Guerre du feu, La (1981), for which he got a Genie nomination. Perlman teamed up with Annaud again in '86, this time as a hunchback named Salvatore in Name der Rose, Der (1986).
His hobbies include golf, jazz, pool and stand-up comedy.
He was ranked in US Magazine's First Annual Reader's Poll - Third runner-up for Best Dramatic Actor as Vincent in "Beauty and the Beast" (1987). 
He was ranked in Star Magazine's Reader's Poll as Best Dramatic Actor as Vincent in Beauty and the Beast (1987).
He attended the Lehman College in NYC in 1971, where he got the Bachelor degree of Fine Arts in Theatre.
Upon meeting to discuss Hellboy (2004) creator, Mike Mignola, and director, Guillermo del Toro, they decided to reveal to each other their choice for the lead role. Revolutions studio wanted a bigger name like Vin Diesel to play the title role, but del Toro fought for Perlman to get the role, and in the end, he did.
He attended George Washington High School.
Ron Perlman attended the University of Minnesota from fall 1971 to spring 1973. In July 20, 1973, he graduated with his then new degree of Master of Fine Arts.
He is good friends with former Beauty and the Beast (1987) co-star, Linda Hamilton. They reunited in the post-Vietnam war drama, Missing in America (2005).
His favorite episode of Beauty and the Beast (1987) is "Happy Life."
To prepare for his role in Hellboy (2004), he read all the Hellboy comics and worked out three hours a day, five to seven days a week. He also worked out while shooting, every day he had off from filming, he would work out.
He broke a rib while filming the subway scenes in Hellboy (2004). He jumped onto a train that was coming towards him.
He is a New York Yankees fan.
With the creation of Hellboy (2004), at age 53, he became the oldest actor ever to play the main superhero.
Ron Perlman was friends with Sammy Davis, Jr. They met at the Golden Globe Awards in the late 80s, apparently Davis was a huge "Beauty and the Beast" (1987) fan and had seen every single episode.
Ron Perlman said in his audio commentary for Cité des enfants perdus, La (1995), that of all the things his characters have done in films, his most hated action was when his character, One, attacked Miette under the influence of the evil Octopus Sisters' drug.
His characters are frequently seen smoking cigars in the films, The Last Supper (1995), Happy, Texas (1999), Price of Glory (2000), Night Class (2001), Hellboy (2004), etc.). Ron Perlman is an avid cigar smoker in real life.
Ron Perlman was offered promotional advertisements as Vincent, his character from the 1987 "Beauty and the Beast" series, but he refused, stating that the character was not there to be exploited.
Ron Perlman doesn't speak French and he was the only American on set of the French 1995 film, Cité des enfants perdus, La. However, he learned all of his lines, and delivered them flawlessly.
He is left-handed, but was forced to use his right as a child. Therefore, he is relatively comfortable using his right hand.
He voiced the narrator in the intro to the video games, Fallout, Fallout 2 and Fallout Tactics.
Ron Perlman plays Hellboy in all live-action and animated Hellboy films.
Ron Perlman voiced Mayor Hoodoo Brown in the video game, Gun.
His favorite movie is Nobody's Fool.
Ron: (on working with Linda Hamilton, looks up at the ceiling, big smile on his face) It was tough. Linda Hamilton is a consummate professional. I don't think I've ever worked with an actor that was more prepared for the day's work than she, and more dedicated to getting it right than she. I thought I was a guy who did his homework, but she caught me a number of times, sort of unprepared and she brought out the best in me. There was no way you could give halfway when you worked with Linda. In terms of her being the beauty, it made my work a lot easier because she was. And she is.
Ron: (on the relationship between Vincent and Catherine The reason why the relationship rings true is that I have a real affection for Linda. I find her an incredible beautiful person and one who possesses a wide range of emotions. Feeling that way about her makes it very easy for Vincent to love Catherine.
Ron Perlman: You draw on your own childhood every time you tee it up as an actor.
Ron Perlman: You do what you gotta do. This is not heart surgery. I'm not curing cancer. I'm just trying to put my kids through school.
Ron Perlman: Yeah, it's nice to get paid for therapy rather than having to pay $240 an hour for it.
Ron Perlman: The great thing about arriving at this age is that I don't even care about my career anymore.
Ron Perlman: I've never worked with a tail, that I can remember. But there's so much I can't remember.
Ron Perlman: I'm thankful to be breathing, on this side of the grass. Whatever comes, comes.
Ron Perlman: I will not do a role that I don't think I can do, that I'm not interested in, where there's no humanity, that doesn't have any kind of handle for me at all because I know I'll just stink the joint up.
Ron Perlman: I think there are a lot of technocrats in the business who would much rather work with just wheels and gears and machinery. Those things interest them more than humanity and I wish them the best of luck.
Ron Perlman: I never direct myself, because I don't like working with me. I would punch me in the mouth if I had to take my direction.
Ron Perlman: I lost 90 pounds and my blood pressure went down to a normal level and the salt in my urine disappeared. And that was when I had to make the transition from fat character actor to thin character actor.
Ron Perlman: I just think that there are those people that their resolve is strengthened by what it is that's keeping them down, and there are some people that will buckle under it. You never know which one is which until you get into the eighth or ninth round of the fight.
Ron Perlman: I don't think anything is ever going to replace the human heart and what that generates in terms of performance.