New York begins falling and Eph and Dutch try to finish their new device before the city gets overrun. Elsewhere: Justine, Gus, and Angel make a final stand against the virus.
The humans begin an assault on Central Park to eliminate the strigoi nest beneath it, and Vasiliy spearheads the efforts. Meanwhile, Dutch and Eph try to translate the strigoi communication patterns, and receive word that Zach is still alive.moreless
Abraham and Quinlan discover the secret to the Master's defeat, forcing Abraham to reach out to a former ally and current enemy for assistance. Meanwhile, Vasiliy tracks tagged strigoi to discover how they are penetrating the safe zones, and Eph and Dutch search for a way to block the strigoi's communication system.moreless
Justine tries to take back NYC after the Master is seemingly killed, but Eichhorst has his own plans. Meanwhile, Dutch finds her way to Eph, and Quinlan discovers that the Ancients are holding back vital information from him.moreless
The battle for New York City continues but the humans find themselves outnumbered and outgunned. Meanwhile, Abraham works with Quinlan to translate the Luman despite Vasiliy's warnings, and Kelly pays Eph a visit.moreless
While Eph and Nora make contact with Zach's grandparents, Lyle threatens Justine with indictment... and turns up dead. Meanwhile, Dutch goes back to Nikki, and Eichhorst tells Eldritch about the true nature of their relationship.moreless
Eichhorst launches a full attack on Red Hook with the Master's strigoi. While Justine and the police fight at the checkpoints, Vasiliy and Nora try to restore the power while Eph and Abraham go after Eichhorst.moreless
Kelly goes after Nora and Zach. Meanwhile, Eph meets with his friend and contacts a pharmaceutical company rep in an effort to get the virus mass-produced so that the National Guard can distribute it.moreless
Eph makes plans to take the virus to the military in Washington, but Nora insists on staying behind with Zach. Meanwhile, Kowalski asks Vasiliy and Dutch for help, and Eldritch takes Coco out for dinner.moreless
Abraham and Dutch go to speak with Eldritch's former bodyguard. Meanwhile, Eph and Nora study the effects of their virus on the strigoi population, and Gus confronts his mother.
Vasiliy and Dutch plan to secure the area by sealing the subway station, while Nora and Eph continue to work on a way to wipe out the strigoi plague. Meanwhile, Eichhorst brings Eldritch a new bodyguard as Vaun and Gus prepare to kidnap the philanthropist.moreless
While Vasiliy and Dutch clean out a local strigoi nest, Nora and Eph experiment on two volunteer subjects to find a way to kill the creatures without killing humans.
A TV producer is accused of molesting his daughter, but the cops suspect the accusations are a ploy when his estranged wife won't cooperate with them, yet she will speak with the media about the matter.moreless
As Big Jim continues to secure his power and takes steps to eliminate Barbie, the Monarch is crowned and the Dome sends a familiar face to Joe and Norrie to reveal the secret of the Dome.moreless
While Harriet goes into labor, Joe and Norrie investigate the source of the Dome in an attempt to save themselves and their fellow townspeople.
When the townspeople realize that their food and water are running out, they begin looting Chester's Mill for whatever remaining supplies that they can find.
Barbie receives word from the outside that the government is drawing their men back as the Dome interferes with magnetic fields.
When Chester's Mill is stricken by a meningitis outbreak, the townspeople panic when the clinic runs out of medicine and the Dome prevents anyone from bringing in new vaccine. Meanwhile, Julia learns the secret that Peter was hiding from her, and Junior is left in charge.moreless
As the reality of their situation settles in, the townspeople's tempers start to fray. Meanwhile, Big Jim sends Reverend Coggins to remove the evidence from Duke's house, and Junior stalks Barbie.
The townspeople of Chester's Mill discover themselves unexpectedly cut off from the outside world when an invisible dome springs up around the town, sealing them in... with limited food, water, air, and medicine.moreless
Kenny and Lazarus search for a guy who plans to detonate a bomb at a public rally. Tonya and White House seek a lost boy's mother, while Ahmad and Jackpot are tasked with conveying a van of prisoners.moreless
Larry inadvertantly becomes a minor hero and causes a stir at Susie's dinner party. Meanwhile, Jeff hopes to land Ricky Gervais as a client, but Larry and a restaurant waiter are roadblocks.