While Miller publishes a story that threatens to destroy Kane, he battles to stay on top, but is concerned over Doyle's alliance with Kitty.
Needing to find a replacement for Stone, Kane hires an ambitious newcomer to the political scene and entices his adversary's aide.
Mayor Thomas Kane attempts to ignore the symptoms and hallucinations of his disease and concentrate on new enhancements to the terminals at Chicago airport.
When Michael reveals his escape plan to Sucre, Sucre chooses to be no part of it, and requests a cell transfer. Michael gets a new cellmate called Haywire.