TC and Topher rush to the scene of a concert where a fireworks explosion has caused massive chaos. As the two jump in to manage the mess, a second explosion causes problems for one of their own. Syd returns from Afghanistan and helps out at the hospital, but finds herself grappling with what the best plans are for herself and her young daughter. Drew tries to help her, but runs afoul of their unique family dynamic. Paul and Shannon must put aside their differences to treat a patient and find out that they have more in common than they thought. Meanwhile, Jordan and Scott treat a patient injured in the fireworks explosion and have a chance to address some simmering differences.moreless
Shannon and Jordan tries to have some fun at a local wrestling event, but instead they find themselves treating people on site when a fight breaks out in the audience. Back at the hospital, Sam attends to a marathon runner who has collapsed from the heat and things start to heat up even more when the air conditioning breaks. Meanwhile, tensions starts to boil between TC, his sister-in-law Annie, Jordan and Sam.moreless
Mr. Peanutbutter's new show is jeopardized by Diane; and Todd inserts himself into international affairs.
A building collapses and TC, Drew and Gwen go to help the injured. When they get there, TC notices that a former army medic has already treated some of the injured. TC asks him to continue helping. In the hospital, Jordan helps a man who has a heart attack when he hears of the building collapse. Paul's father, a renowned neurosurgeon shows up and is pressuring Paul to go to Johns Hopkins and become a surgeon.moreless
In the series finale, Moretti goes missing on the day of her wedding, and Pierce soon discovers that she's been abducted by a dangerous person from his past.
Pierce attempts to find the killer of a student while defending the victim's boyfriend, who is believed to be mentally ill and guilty of the crime. Pierce has to face up to his feelings about Kate as her wedding day nears.moreless
Pierce and Moretti stumble on an international scandal when investigating the murders of a Bangladeshi diplomat and a Chicago reporter. Kate struggles as she prepares for her wedding so she asks Pierce for help.moreless
Moretti goes undercover to investigate the brutal murders of meat-company owners. Meanwhile, Pierce contemplates making a personal confession to Moretti.
Daniel's father and his friend Dean Haley are faced with the decision on whether to allow Pierce to undergo a high-risk surgery for his traumatic injury. Daniel works on solving a different kind of murder case.moreless
Pierce helps Donnie when Donnie finds himself in a compromising situation and evidence stacks up against him. Meanwhile, Pierce's father assaults someone at an assisted-living facility.
A sniper targets the Federal Building lobby, putting Moretti and Donnie in the crosshairs. Before long, Pierce concludes that the shooter fears low-frequency radio waves. Meanwhile, a beguiling woman prompts Donnie to run for office.moreless
A missing FBI agent is found dead in an investigation that forces Pierce to face a past unsolved case, and Pierce's therapist grows concerned that the investigation may exacerbate Pierce's condition.