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Amnesty International and Shelter are the charities that Sienna supports.
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Sienna and Enzo took part in cycling for Tour de France to raise money for charity.
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In 2002, she was named as one of Maxim magazine's 'Hundred Sexiest Women.'
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Sienna played the title role in John Kent Harrison's film Helen of Troy.
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In the year 2000, readers of the men's magazine Esquire voted her Britain's Most Eligible Woman.
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In the 1990s, Sienna took the unusual career step of giving up acting for a few years to become a top fashion model.
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She was educated as a day girl at Gresham's School, Holt, which is a traditional English boarding school founded in 1555, and later trained as an actor and musician at the New World School of the Arts and the Paris Conservatoire.
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Sienna's mother, Tina, designs and manufactures country clothes, and Sienna has sometimes modelled her mother's work for catalogues of the current collection.
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Sienna has a sister named Jace. She also has a much younger half-sister called Eleanor Guillory, born in 1994, and a half-brother, Easton Jacob Guillory, born in 1998.
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Sienna's parents divorced when she was thirteen. Her father moved to the north of England, where he remarried and had two more children.
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Born in London, she grew up mostly in the rural district of North Norfolk in East Anglia, where she went to school.
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Her mother, Tina Guillory, is English and now has a farmhouse in the east of England.
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Sienna's father was the late Isaac Guillory, an American singer, song-writer and guitarist who was born at the Guantanamo Naval Base in Cuba. He died of cancer in December, 2000.