Coulson and Gonzales are forced to join forces with an unreliable ally to defeat Hydra.
The team deals with the revelation of Skye's altered nature, while Bobbi and Mack tell Lance where their true allegiance lie. Meanwhile, Grant and Agent 33 go on a personal mission.
While Jemma secures the Kree city, Skye is put into quarantine. Meanwhile the team carries out an operation against Hydra to eliminate the people who arranged Trip's death.
While Coulson's team tries to track down the secret, they meet the Doctor. Meanwhile, Bobbi interrogates Sunil and Ward kidnaps his older brother.
Someone is killing people and leaving the alien writing etched on the corpses. As Coulson's team pursues the murderer, they discover a connection to their director's past.
An undercover Jemma finds herself the subject of a security crackdown by Hydra's security chief, Bobbi Morse. Meanwhile, Raina tries to negotiate with Coulson to get the obelisk before Whitehall has her killed.moreless
Coulson and Melinda go undercover to obtain a painting that may hold the answers to Coulson's attacks. Meanwhile, Fitz fights his own problem to help the team when the Bus is sabotaged, while Whitehall forces Raina to bring him the obelisk.moreless
Jemma puts her cover as a researcher for Hydra at risk to stop her new organization from acquiring Donnie Gill, a Gifted who could prove valuable to both sides. Meanwhile, Fitz confronts Grant for the first time since Grant tried to kill him.moreless
While Coulson and his team try to stop Hydra from getting the obelisk from Creel, Talbot continues his pursuit of the fugitives. Meanwhile, Mack reaches out to Fitz, while Lance must consider his future after he loses his friends.moreless
Coulson and his team go underground to continue the fight against Hydra. Besides dealing with the American government's attempts to capture them, the team must track down a World War II artifact of amazing power.moreless
Jones takes the leadership position from Amanda at The Shop, then calls Nikita and offers her and her team complete freedom by wiping away their identities and faking their deaths if they drop their mission. The team lands on a secluded Pakistan air strip, but a local drug czar and his men storm the plane and demand ten million dollars, and Nikita turns to Alex for the money. Alex removes some diamonds from a safe deposit box to make the payment, and Sam sees an opportunity to recoup his losses and considers stealing the diamonds. Meanwhile, Michael comes face-to-face with an old rival, Ramon, who hits Michael with some hard truth.moreless
Calder makes himself Annie's handler and sends her to Vienna to seek out a Greek arms dealer. Calder forbids any communication between Annie and Auggie while she's on her mission. Arthur and Joan discuss how Calder is probably Henry's new mole inside and how they can get out in front of Henry's game.moreless
Nikita is upset when Birkoff tells her that information in the black box indicates a man named Ramon, who she captured years earlier and turned over to Percy, is now working for Division as an assassin. Amanda convinces Alex to kill Anton Kochenko, a man who once worked for her father, and sets up Ramon so that he will be charged with the murder. However, when Nikita interferes with Amanda's plan, Amanda retaliates by taking what Nikita values most.moreless