Sprague is five feet and five inches tall.
Sprague was among Inside TV magazine's 50 Hottest New Faces on Television in 2005. She was also christened TV's Sizzling New Star in 2007 by Netscape Celebrity.
Being raised in Manchester, Massachusetts, Sprague grew up with a steady diet of lobster, fish, clam chowder, roast beef sandwiches, chicken, broccoli, and rice.
When she is off from work, Sprague likes to walk on the beach, ride her bike, and go hiking. She also works out a lot, does cardio, Pilates, and bikram Yoga.
IMDB lists Grayden to be in a 2008 movie called Level Seven. Sprague denies that she is part of such a project and has tried thru her agents to have the entry removed, to no avail.
Sprague collects Pez dispensers. She already has a huge collection in her apartment that keeps on growing since people keep giving them to her. She has them stored except for the special ones which she displays.
Sprague considers her recurring role in Six Feet Under as Anita as her biggest break.
Sprague's theater credits include Waiting For Lefty and Ordinary Day, Hamlet, Fool For Love, The Vagina Monologues, Hopscotch, A Midsummer Night's Dream, As You Like It, The New York Sex Comedy and The Tempest.
Sprague started her performing career as a child by appearing in commercials. A casting agent, who was a friend of her parents, saw her dancing in a party they were attending and proposed the idea to them.
Sprague attended Manchester-Essex Regional High School.
Sprague appeared in a local play entitled Strong Man's Weak Child which was written and directed by Israel Horowitz.
"Sprague" is her mother's maiden name.
Sprague: Secretly, I'm a real big nerd. I'd rather stay home and play Scrabble than go to a Hollywood party, any day of the week. And I love reading about history and watching the Discovery Channel.
Sprague: If you just stay away from junk, and stick with what your mom taught you, you're eating pretty healthy.
Sprague: (advice for girls on staying healthy) Some girls need to remember that in this country, we only seem to see extremes. People are either anorexic, or they're obese. The fact of the matter is, you should be in the middle. If you're hungry, you're still growing, and you need to eat. I was lucky I was raised by parents who gave me a lot of sense of self and a lot of confidence in myself.
Sprague: I think I'm a part of all the characters I play, definitely at different times in my life. In real life, I'm kind of a tomboy. I like to read a lot I like watching T.V. I don't think I'm as interesting as my characters, but I like doing what I do.
Sprague: (on surviving a nuclear attack) Make sure you know how to make bio-diesel ahead of time. Make sure you have a lot of cars before 1960, because after an EMP they still work.
Sprague: My parents decided my education was more important, and it worked really well for me.
Sprague: Having a college degree, this business is not an easy business, and you never know where your career is going to go, and you're lucky to keep working and savor every moment of it. But if it ever comes to a point where I'm not working anymore, I have this incredible other option, I could go to graduate school or I could pursue a lot of other fields. It's very freeing in a lot of ways. I'll never feel like I have to continue performing, if I don't want to.
Sprague: [Education] allows you the opportunity to really love and appreciate your art.
Sprague: You just have to keep choosing work you believe in. Look for the good writing, hopefully the great writing, the fully formed characters. If you're loving what you do, the work will always come.
Sprague: Not everyone has a brother or father in Iraq, which makes it easy to turn your head, but this show [Over There] instigates conversations that are not otherwise occurring.