While Coulson, Fitz, and Mack try to identify who is responsible for a series of blackouts, Jemma and Holden try to save Melinda, while Daisy learns more about Robbie and Gabe.
Escaped convict Luke Cage, who is trying to keep a low profile in Harlem despite his super-strength and near-invulnerability, gets drawn into danger when a pair of cousins try to take control of the neighborhood.moreless
Daisy goes back to confront Robbie, suspecting a connection between the mysterious "Ghost Rider," the ghosts, and the gangs allying together. Meanwhile, Coulson meets with the new Director while Melinda's condition deteriorates.
S.H.I.E.L.D. is legitimized again, and Coulson and Mack lead the field investigations while Melinda trains a new strike team, and Fitz and Jemma continue their relationship.
Coulson and his team take on Hive before he can set off the warhead and transform the world's population into his Inhuman slaves. However, one team member will sacrifice themselves to stop the Inhuman leader.moreless
Hive's master plan is completely revealed, forcing S.H.I.E.L.D. into action.
Talbot demands that Coulson register the S.H.I.E.L.D. Inhumans, and is less than thrilled to learn about the threat of Hive. Meanwhile, Daisy helps Lincoln to escape the base so that he can join her.moreless
While a S.H.I.E.L.D. strike team goes after Hive, Mack tries to rescue Daisy before it's too late. Meanwhile, Fitz and Jemma create an anti-toxin against Hive's parasites, and Lincoln insists on testing it on himself.moreless
Fitzsimmons tries to find a way to stop Hive as he continues to recruit Inhumans to his side.
Gideon wrestles with his past as Hive calls a meaning of Hydra's inner council. Meanwhile, Daisy and Lincoln look for a former Afterlifer with information on Hive, while the others investigate Hydra's newest business acquisition.moreless
Daisy gets a terrifying glimpse into the future and S.H.I.E.L.D. tries to prove her vision isn't set in stone.
A new group, the Watchdogs, go public and destroy an ATCU facility as they declare on the war on the Inhumans and the ATCU. Meanwhile, Mack tries to spend some downtime with his brother.moreless
Bobbi and Hunter follow Gideon to a compound in Russia, and discover what he has in mind for the Inhumans in Russia.
President Ellis sponsors an international symposium on the Inhuman problem, and Coulson and Talbot must attend it. Along the way, they try to find Malick's inside man. Meanwhile, a foe from the past makes a return, and the team find a potential vaccine against Terrigenesis.moreless
Coulson and President Ellis come to an arrangement, and Coulson begins the hunt for Malick. Meanwhile, Daisy leads a team to Bogota to track down a rogue Inhuman, and discovers that there's more involved than they first thought.moreless
Peggy tries to trade Jason for the uranium rods that Whitney wants, but her plan doesn't go as intended. Meanwhile, Jarvis vows to kill the person responsible for Ana's injuries.
Jack comes up with his own plan to stop Vernon and Whitney, but things don't go as he expected. Meanwhile, Jarvis makes a startling confession to Peggy.
Peggy recruits an ally to help her gain a sample of zero matter so that Jason can restore himself to corporeal form. Meanwhile, Vernon warns Jack that he has to get Peggy under control, and the Council of Nine undergoes a restructuring.moreless
While Peggy and Jarvis go to rescue Dottie from Whitney, Whitney initiates a plan of her own while securing her position as the new head of the Council of Nine.
Peggy and her off-the-books team must find a way to stop the Council from detonating an atomic bomb in California.
Peggy and Jarvis abduct Rufus, and Peggy interrogates him about the Council of Nine. Meanwhile, Whitney works on controlling her newfound power, and Vernon pays the SSR a surprise visit.
Isodyne frames the dead Jason Wilkes as a Communist spy, but Peggy insists that he's innocent and tries to clear the scientist's name. Meanwhile, Jack flies out to LA to shut down the SSR's investigation into Isodyne thanks to the influence of his friend Vernon.moreless
Peggy is reassigned to LA to help new bureau chief Daniel with the case of a deep-frozen corpse... and the freezing temperatures are contagious. Meanwhile, Jack's patron informs him that the SSR's days are numbered.moreless
While Peggy continues her investigation into Isodyne, Daniel is surprised when she and his new girlfriend hit it off. Meanwhile, Jason asks Peggy for help and offers her a way into the company.moreless
On the alien planet, Coulson hunts down Grant to get revenge for Rosalind's death. Meanwhile on Earth, the team secure the portal in the hopes of bringing their comrades home.
Coulson swears to do whatever it takes to bring in Grant, after the rogue agent strikes at someone close to Coulson. Meanwhile, Gideon captures Jemma and Fitz, and Mack convinces Joey and Lincoln to join the new team of Inhumans.moreless
While Coulson's team infiltrate the ATCU base, Coulson interrogates Rosalind about what they discover during the break-in. Meanwhile, Gideon explains to Grant the true origins of Hydra.
While Fitz helps Jemma recover the information from her phone that could help the team open the portal, Coulson and Rosalind join forces to track down Andrew after Lincoln comes in out of the cold to confirm that Andrew is Lash.moreless
Coulson accompanies Rosalind to the ATCU facility, while Daisy, Mack, and Lance run surveillance on Banks. Meanwhile, Melinda takes Bobbi with her to track down the man who attacked Andrew.
Jemma tells Fitz about what happened to her on the alien planet... and the man who helped her survive.