While Fitz tortures Daisy, Jeffrey engineers a plan to rescue a valuable prisoner--and his intel--from captivity.
Jemma tries to get to Holden to convince him to show them how to escape the Framework. Meanwhile, Daisy works from within Hydra to help her friends.
Hydra controls the world within the Framework, and only Daisy and Jemma realize that something is seriously wrong.
Holden sends more LMDs to infiltrate the S.H.I.E.L.D. base as part of his plan to expand the Framework.
Coulson and his team try to find the captive Jeffrey before it's too late.
While Jeffrey and Daisy go after an Inhuman who can generate explosions, Coulson and Mack meet the woman who served as the basis for Aida's physical appearance.
When the organization behind the Watchdogs abducts Billy Koenig to get the Darkhold, Coulson and his team spring into action to rescue him and prevent the Book from falling into enemy hands.
While Aida plans a new move against the team, Melinda tries to find out what really happened to her.
Coulson and Mack learn the truth about Jeffrey after saving his life from an assassination attempt. Meanwhile, Holden continues his plan to infiltrate S.H.I.E.L.D. with his LMDs.
Aida continues her search for the Darkhold, while Coulson remains unaware of "May"'s true nature.
S.H.I.E.L.D. teams with Ghost Rider to stop Eli from destroying Los Angeles... and possibly the world.
With Ghost Rider running out of time and half of the team the gone, the others try to deal with the Darkhold.
Robbie's back story is revealed as Coulson and his team fight for their lives.
S.H.I.E.L.D. infiltrates a high-security prison to find out more about the Darkhold, while Ghost Rider fights to emerge from Robbie.
While Daisy teams up with a figure from the past to bring down the Watchdogs, Coulson and Mack square off against Ghost Rider.
While Coulson, Fitz, and Mack try to identify who is responsible for a series of blackouts, Jemma and Holden try to save Melinda, while Daisy learns more about Robbie and Gabe.
Daisy goes back to confront Robbie, suspecting a connection between the mysterious "Ghost Rider," the ghosts, and the gangs allying together. Meanwhile, Coulson meets with the new Director while Melinda's condition deteriorates.
S.H.I.E.L.D. is legitimized again, and Coulson and Mack lead the field investigations while Melinda trains a new strike team, and Fitz and Jemma continue their relationship.
Coulson and his team take on Hive before he can set off the warhead and transform the world's population into his Inhuman slaves. However, one team member will sacrifice themselves to stop the Inhuman leader.moreless
Hive's master plan is completely revealed, forcing S.H.I.E.L.D. into action.
Talbot demands that Coulson register the S.H.I.E.L.D. Inhumans, and is less than thrilled to learn about the threat of Hive. Meanwhile, Daisy helps Lincoln to escape the base so that he can join her.moreless
While a S.H.I.E.L.D. strike team goes after Hive, Mack tries to rescue Daisy before it's too late. Meanwhile, Fitz and Jemma create an anti-toxin against Hive's parasites, and Lincoln insists on testing it on himself.moreless
Fitzsimmons tries to find a way to stop Hive as he continues to recruit Inhumans to his side.
Gideon wrestles with his past as Hive calls a meaning of Hydra's inner council. Meanwhile, Daisy and Lincoln look for a former Afterlifer with information on Hive, while the others investigate Hydra's newest business acquisition.moreless
Daisy gets a terrifying glimpse into the future and S.H.I.E.L.D. tries to prove her vision isn't set in stone.
A new group, the Watchdogs, go public and destroy an ATCU facility as they declare on the war on the Inhumans and the ATCU. Meanwhile, Mack tries to spend some downtime with his brother.moreless
Bobbi and Hunter follow Gideon to a compound in Russia, and discover what he has in mind for the Inhumans in Russia.
President Ellis sponsors an international symposium on the Inhuman problem, and Coulson and Talbot must attend it. Along the way, they try to find Malick's inside man. Meanwhile, a foe from the past makes a return, and the team find a potential vaccine against Terrigenesis.moreless
Coulson and President Ellis come to an arrangement, and Coulson begins the hunt for Malick. Meanwhile, Daisy leads a team to Bogota to track down a rogue Inhuman, and discovers that there's more involved than they first thought.moreless
On the alien planet, Coulson hunts down Grant to get revenge for Rosalind's death. Meanwhile on Earth, the team secure the portal in the hopes of bringing their comrades home.