At the Screen Actors Guild Awards in 2006 she was nominated for Outstanding Performance by a Cast in a Motion Picture for the movie Hustle & Flow shared with Anthony Anderson, Ludacris, Isaac Hayes, Terrence Howard, Taryn Manning, Elise Neal, Paula Jai Parker, DJ Qualls.
Taraji Henson: (On playing Tiffany in the Lifetime movie Taken From Me: The Tiffany Rubin Story) I had never played a real-life person up until that point. All of my characters had been fictional, so there was an excitement to playing a real person and then her story is amazing... ...I've always liked playing women who are victims but who don't settle for being a victim.
Taraji Henson: (On inspiration for playing the role of Tiffany in the Taken From Me: The Tiffany Rubin Story) Being a mother made me totally understand her struggle and why she fought so hard. It just made me understand her emotional roller coaster. I really didn't have to do too much acting because I just put myself in her shoes and what I would do if my son was in another country and I didn't know anything about it.
Taraji Henson: (On how the Lifetime movie Taken From Me: The Tiffany Rubin Story is a wake-up call for abductions) You kinda know when a situation happens and it's in the media and it's big and then it goes away. It made me remember how many kids-how many families-are going through this. It reminded me that it's still an issue.