Although he usually plays earnest protagonists, he played an antagonist on "King of the Hill" when he was guest-starring on the program "King of the Hill: Mega Lo Dale" along with fellow "That '70's Show" co-star Danny Masterson. The second time was his doing the immortal role of Edward Brock, Jr./Venom in "Spider-Man 3." The third time was guest-starring on "The Simpsons: The DeBarted" as Donny Douglas.
The producers of "Spider-Man 3" chose him for the plum role of the arch-nemesis Eddie Brock, Jr. based on his performance in the 2004 picture "In Good Company."
For his entire six year run on That '70s Show, Topher wore a wig to achieve the hairstyles that were common with young men in the late 1970s.
During a 2007 taping of The Late Show, David Letterman introduced his next guest, Tobey Maguire, but as a joke, Topher Grace came out instead and tried to pretend he was Tobey.
Although Sony Pictures is planning to proceed with a spinoff film based on the Spiderman villain Venom (played by Topher Grace in Spiderman 3), the studio executives are not certain they want Topher to reprise the role.
When Topher was a child, future actress Chloe Sevigny worked as a babysitter for him and his younger sister, Jennifer in addition to growing up in the same town as Kate Bosworth.
Awards and Nominations: - Won an Emmy Award for Outstanding New Approaches - Original Daytime Program or Series in his work The Beauty Inside. Won a National Board of Review of Motion Pictures Award for Best Breakthrough Performance by an Actor for In Good Company (2004) - Won a National Board of Review of Motion Pictures Award for Best Breakthrough Performance by an Actor for P.S. (2004) - Won a 2001 Screen Actors Guild Award for Outstanding Performance by the Cast of a Theatrical Motion Picture for Traffic (2000) - shared with: Steven Bauer, Benjamin Bratt, James Brolin, Don Cheadle, Erika Christensen, Clifton Collins Jr., Benicio Del Toro,, Michael Douglas, Miguel Ferrer, Albert Finney, Luis Guzmán, Amy Irving, Tomas Milian, D.W. Moffett, Dennis Quaid, Peter Riegert, Jacob Vargas and Catherine Zeta-Jones
- Nominated for a 1999 Young Artist Award for Best Performance in a TV Series - Young Ensemble for That '70s Show - shared with: Laura Prepon, Mila Kunis, Wilmer Valderrama, Danny Masterson and Ashton Kutcher
- Won a 2001 Young Hollywood Award for Breakthrough Performance - Male for Traffic (2000) - Nominated for a 2007 Teen Choice Award for Choice Movie: Rumble for Spider-Man 3 (2007) - shared with: Tobey Maguire, James Franco and Thomas Haden Church - Nominated for a Teen Choice Award for Choice Movie: Villain for Spider-Man 3 (2007) - Nominated for a 2004 Teen Choice Award for Choice Movie Actor - Comedy for Win a Date with Tad Hamilton! (2004) - Nominated for a 2004 Teen Choice Award for Choice Movie Hissy Fit for Win a Date with Tad Hamilton! (2004) - Nominated for a 2004 Teen Choice Award for Choice Movie Liplock for Win a Date with Tad Hamilton! (2004) - shared with Kate Bosworth - Nominated for a Teen Choice Award for Choice TV Actor - Comedy for That '70s Show every year from 2000 through 2004 - Nominated for a 1999 Teen Choice Award for TV - Breakout Performance for That '70s Show
Topher enjoys playing tennis and even considered playing professionally, but that dream was ended by injuries to his ankles. He also enjoys soccer.
Aside from school plays, Topher had no acting experience before landing the role of Eric Forman on That 70s Show.
During the filming of Spiderman 3, Topher disliked being in the Venom costume because he found it extremely hot and uncomfortable. In addition, the false teeth he had to wear would bruise his gums.
His immediate family consists of his parents, John and Pat Grace, and his sister, Jennifer Grace.
As he is a fan of Star Wars: A New Hope, he conceived of the idea to film an episode of That 70s Show with a Star Wars theme.
Topher's favorite That 70's Show episodes are "The Pill," "I Love Cake," "Eric's Panties," "Love Wisconsin Style," and "Celebration Day."
Topher owns a Border Terrier named Max .
Not one to let his success go to his head, Topher drives a 1985 Volvo, a green Honda, and Volkswagen Jetta.
Bill Murray tops Topher's list of favorite actors, and Reese Witherspoon is one of his favorite actresses.
Topher had expressed an interest in working with directors Richard Linklater, PJ Hogan, Robert Zemeckis, Spike Jonze, Steven Soderbergh (again), and Steven Spielberg.
Topher filmed all his scenes in P.S. in 14 days.
Since all of his friends would shorten his given name from Christopher to Chris (which he did not like), he began using the half of his name that everyone else seemed to discard (Topher).
Topher left That 70's Show after seven seasons along with Ashton Kutcher, but returned sporadically as a guest star in the final season.
Topher stands tall at five feet, eleven inches.
Topher: I introduced myself as Christopher but nobody [in the US] will call you more than one syllable. It happened when I went to boarding school. I'd say, "Hi, my name is Christopher," and they'd say, "Hi Chris." "And I'd say, '… topher.'" And that's how it started!
Topher: I bought an apartment in New York, but I don't have time to go there … I try not to live beyond my means or to do anything out of character for a 26-year-old. My friends don't have as much money and I don't want to alienate anyone.
Topher: Fathers give us a road map to life and my dad is very much like Dennis Quaid's character. My dad has cried very infrequently, but at the end of this movie he was in pieces. It's a father-son movie about corporate America, and it's like I wrote the film for him.
Topher Grace: (about his immenent departure from "That '70s Show") It's heartbreaking, because there's no funner job in the universe than being one of those six kids. I was in my teens when I started. It's ridiculous to even try to imagine my life without being able to laugh all day with those five people. I never cry, like ever, but I have a feeling it's coming.
Topher Grace: (discussing filming "That 70s Show" during an interview in 2001) The show is now like a game of trying to not laugh during takes, you know, to not break character and laugh. It's so much fun.
Topher Grace: I was in the 8th grade, and I got up the nerve to ask this girl to a dance. I had a really big crush on her, but she had no idea. She was at her locker, and I just walked up to her and blurted it out. She just said, 'No.' She didn't try to lessen the blow by saying, 'I'll see you there,' or something. I think she even laughed a bit. And I remember everyone in the hallway watching.
Topher Grace: I do like any kind of project that has both comedy and drama in it because in life you don't have one day where everything is funny then the next day everything is dramatic.
Topher Grace: There is a way people like to compartmentalize you on sitcoms and I've been very cognizant of not letting that happen.
Topher Grace: (during an interview early in his career) I'm really open about talking about how green I am and how I want learn. I want to be the least good person in any project I do.
Topher Grace: I don't talk about my personal life with the press.
Topher Grace: (on starting his acting career on That '70s Show) I had to ask things like, 'Who is Nipsey Russell?' and 'What was Petticoat Junction?'... I play an awkward teenage boy who gets rejected. I've done so much research in that department, I can't even begin to tell you... Sometimes I look at the clothes, I wonder, 'What the hell were they thinking?'