Devane has played tough-guy roles in such notable films as Family Plot, Hollow Man, and Testament. He has also appeared in countless television productions, most memorably as the corporate cad in Knots Landing and as the Secretary of Defense James Heller in 24.
Devane has been married to his wife, Eugenie, since 1961. He owns two Italian restaurants in Southern California, which he operates with his sons. Devane loves all manner of equestrian sports.