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William's son, Andrew, operates a lawn-and-gutter service in Raleigh, N.C., called The Blade Runner.
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As a boy growing up in Memphis, Tennessee, Sanderson delivered The Commercial Appeal newspaper, played youth baseball, and attended Bellevue Baptist Church.
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Sanderson received a Distinguished Alumnus award from the University of Memphis in 2008.
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William and his wife, Sharon, have homes in Burbank, California and Harisburg, Pennsylvania.
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Cracked magazine named William Sanderson one of its "15 Funniest People of 2006," for his comedic portrayal of E.B. Farnum on Deadwood.
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Sanderson has appeared in Los Angeles in plays such as "Authentic Life of Billy the Kid" (Directed by Tommy Lee Jones), "Tobacco Road," "Scotch Rocks," and "Ground Zero."
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Sanderson has appeared in the following productions on the New York stage: "To Kill a Mocking Bird," "Hello Out There," "When You Comin' Back Red Ryder," and "The Taming of the Shrew," as well as other shows.
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While a teenager William used his ability to portray different characters to sneak into concerts and sporting events for free.
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Sanderson has played the "sleazy" character in so many westerns that he says his specialty is playing "prairie scum."
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Sanderson has appeared in many westerns, such as "Last Man Standing," with Bruce Willis, "Lonesome Dove," with Robert Duvall, "Monte Walsh," with Tom Selleck, and most recently in HBO's "Deadwood."
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Sanderson's role as Larry, along with his brother Darryl and his other brother Darryl, in Newhart was intended to be a one-time appearance. The characters were so well accepted they became regulars through the rest of the series' run.
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William appeared in four projects with Tommy Lee Jones: "Coal Miner's Daughter," "The Client," "Lonesome Dove" and "The Executioner's Song."
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While in the U.S. Army Sanderson served as a medic.
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William's mother was an elementary school teacher, and his father was a landscape designer.
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Sanderson appeared in two films with Sissy Spacek: as Loretta Lynn's uncle in "Coal Miner's Daughter" (1980) and as Calvin in "Raggedy Man" (1981).
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Early in his acting career William appeared in over thirty off-Broadway stage productions.
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After a stint in the Army, Sanderson graduated from Memphis State University and then attended its law school.
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He married Sharon Wix on December 5, 1993.
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William Sanderson played a part in the movie Blade Runner where he designed human-like robots. Later, he played a role in Batman: The Animated Series where his character did the same thing.