Barkio looks and sounds exactly like Lucky, despite the fact that it shouldn't be possible for Roger to know how Lucky would sound if he did talk.
Lucky, Rolly and Cadpig used up all the explosive eggs to take out the giant worm, but just as the pups and Cruella got into the catapult, Lucky suddenly had an egg appear in his mouth.
Rolly: No fair! She gets the Lawnmower of Death, and we get a hay ride!
Cruella: If it makes you feel any better, think of it as the Hay Ride of Death!
(The main pups have all literally become one.)
Rolly: Hey, what's going on?
Lucky: We've all become Barkio.
Cadpig: At last! Supreme oneness! Jointedness! Togetherness! When is it over?
Announcer: The third and final round...Farmegeddon!
Cadpig: Oh, that sounds encouraging.
Cruella: I can't remember the last time I enjoyed a bad hair day!
Cadpig: Since when do motorcycle gangs value fighting fair?
Rolly: Remember, Roger wrote this game.
Cadpig: Oh yeah. Question answered.
Cruella: I can't believe I'm taking survival advice from someone in a flea collar.
Cadpig: Does anyone else sense tension here?
Rolly: That looks like Cruella's house.
Cadpig: ...before she changed the style from early Gothic strange to late, weird and tasteless.
Lucky (in Cruella's obscure mansion): I don't understand. It's like I'm in some modern art painting. (he then goes down a twisted staircase) I hate modern art.
Cadpig: Rolly and I add another eight pounds. We need a hundered more.
Lucky: How 'bout Cruella, I bet she weighs a hundred pounds.
Rolly: Yeah, so do a bunch of rocks.
Cadpig: I vote for the rocks.
Cadpig: Roger calling this computer sorta buggy is like saying Cruella is kinda selfish.
Cruella: Don't be absurd, I was giving your video game a test run, that's all.
Roger: Well, it really wasn't ready yet but, what did you think?
Cruella: Well, it teaches fair play, cooperation, and team work. I didn't much care for it.
Roger: No, Lucky. This isn't a game for pets.
Cruella: It's mine!
Roger: No, Cruella. This isn't a game for pests... uh, I mean, uh... fashion designers.
Cruella's Memo: Vaporize hair dresser.
We find out in this episode that Rolly and Cadpig's weight combined is equalled to approximately 8 pounds.
When Lucky entered Cruella's house it resembled the famous painting entitled Crazy Stairs. It is a painting done by M. C. Escher.
Barkio: I am Barkio.
The name Roger gave his character, Barkio, was most likely inspired by Shigeru Miyamoto's Mario, the mascot of the video game company, Nintendo.
In addition to that, the opening sequence of the game where we see Barkio's floating head is a reference to the opening sequence of Super Mario 64.