The quote is from Judging Amy. I never watched the show and I got the quote from a friend. This show does a great job with episode titles as each storyline always somehow connects back to the title.
I thought this was the best episode of the series. From Michael trying to keep Lily alive to Zeke trying to control his friend's Scotty's health and Scotty trying to hang on to not being the guy with cancer again, the thread of letting go is ever present.
Letting go is a part of life and it's seldom easy, especially when you are not ready for it. I've had a lot of life experience in this area as I suspect we all have and this episode has some very touching moments. Very well done.