During the year 1827 in Edinburgh, Scotland, John McGregor must take care of his alcoholic wife Aggie. He works for Dr. Knox and must lug large boxes of tanbark to his medical academy. When John learns that the boxes actually contain the murdered victims of two bodysnatchers Burke and Hare, he decides to get rid of his wife by getting her drunk and leaving her on the bodysnatchers' doorstep. The plan is successful, but John is overtaken by remorse. Unfortunately, he ends up to be Burke and Hare's next victim.