In the scene where Tommy is telling his grandpa that he's embarrassing him, Grampa Louis gets mad and says that because he's old and has a hearing aid. then he proceeds to pull up his underwear, but it sounded if he was wearing a diaper.
In the scene where Grandpa Lou looks at the giant heart, where Tommy and the other kids are trapped, you see that the door that leads inside the heart is open. But a few seconds later, when you see Tommy inside, you see the door is blocked.
In one scene, Phil's hair turns a dark reddish color. Then in the next scene it's back to normal.
Chuckie: Now I know why it was called the spleen screeeeaaaammmm!
Phil: (Receives the liver key chain) Cool. Now I have a liver inside and out. Love the key chain.
Lil: Good. But you still need a key.
Lil: We're catching up fast.
Phil: Yeah, but it'd be nice if we could at least stop and smell the mucus.
Chuckie: (About his key chain) I'm giving this one to Kimi, 'cause she's a good kid... ney. Get it? Kid-ney? (The others stare at him blankly) Okay, off to the thigh.
Mr. Beaker: And that's what makes the appendix one of the most impressive, yet utterly useless organs.
Grandpa Lou: And that's the story of the day they wrestled out my tonsils. Or was it my gall bladder? Well, it was something floating in a jar.
Mr. Beaker: (To class) And now for something really breathtaking - the lungs.
Phil: (About the orgain key chains) I am definitely going to sport that key chain with pride.
Lil: You don't have any keys.
Phil: Do you know you're a very negative human being?
Tommy: My Grandpa may do some embarrassing stuff sometimes, but he's still my Grandpa. So shut your pie hole!
Grandpa Lou: If that heart's on the fritz, why is it beating?
Didi: Dil! Your steamed spinach on a bed of chilled spinach is getting cold! And warm!
Phil: Man, the Spleen Scream is one more fun thing we won't be doing today. Which also means we can say adios to our key chains.
Lil: I know. Bringing Grandpa Lou wasn't exactly a great idea. What was Tommy thinking?
Sean: I'm too young, cool, and popular to die.
Dil can burp the 50 states.
The sign in front of the heart exhibit, indicating it's closed, reads: "Please excuse us while we mend our broken heart."
Earlier in the episode, Justin's voice is similar to Nick Dean, from The Adventures of Jimmy Neutron: Boy Genius. Later, Justin's voice sounds more like Snap from ChalkZone. Those three characters are all played by Candi Milo.
Justin's name is never mentioned, except in the credits.
Alternate Episode Title: "The Ileum and the Odyssey."
Kimi, Susie, and Angelica are absent in this episode.
Episode Title: The Old & the Restless
This is a spoof of the long-running soap opera, The Young and the Restless.