American Dad!

Biggie Smalls / Notorious B.I.G. In one of Roger's memories, he is seen driving a car with rapper Christopher Wallace (aka "Biggie Smalls", aka "Notorious B.I.G.") in the front passenger seat. At a red light, Roger harasses and upsets another driver who then pulls out a gun and shoots Biggie, killing him. This is a reference to the death of Biggie Smalls who was killed in a similar drive-by shooting on March 9, 1997 by an unknown assailant. This scene implies that Roger was the driver and cause of Biggie's death, though in actuality, the driver was Gregory "G-Money" Young and the cause is rumored to be rap-feud related (eg. a feud between East-coast and West-coast rappers).

Alien While in the mind of Roger (an alien), Stan sees Tom Skerritt in a cocoon, stuck to the roof of a cave. This is a reference to a deleted scene from the 1979 movie Alien in which Skerritt's character suffers the same fate at the hands of an alien.

Small Wonder The robotic girl named Vicki seen in Roger's mind is from the show Small Wonder.

Jiminy Cricket Roger's conscience bears a striking resemblance the character in Disney's Pinocchio.

Episode Title The title is a take on the movie, Trains, Planes and Automobiles.