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Goof: During "The Wishing Star", the mime sings with the citizens of Warnerstock, even though mimes are supposed to be silent.
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Goof: Plotz fires a cannonball into Dr. Scratchansniff van but the cannonball comes in from the front, leaving a hole in the back, despite the fact that before and after, Plotz is behind them.
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When the Warners go throught the "Cave of Your Worst Nightmares", they meet people that scared them in past episodes: Mr. Director from Hello, Nice Warners, the creepy gas station worker and his gross bathroom from Potty Emergency and Baloney the Dinosaur from Baloney And Kids.
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In the bar Mo-Ron, Fan Boy and Freakazoid play the "Freakazoid!" Theme.
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With the money they got from their movie, Yakko, Wakko and Dot are now the major stockholders of the studio.
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At one point during the Warners' song Plotz goes from a tuxedo to his regular (nonshabby) business suit and back into a tux. Major animation gremlin!
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Rita and Runt can be seen on the milk carton that Yakko has with him.
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Animaniacs cameos: Yakko, Wakko, Dot, Pinky, Brain, Slappy, Skippy, Mindy, Ralph, Buttons, Dr. Scratchensniff and Hello Nurse.
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One of the sailors in the Moby Dick-based portion of the song greatly resembles Lucky Bob from the later WB cartoon Histeria!
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When shown on Nickelodeon, most of the "We Are Pests" song was cut, including the dialogue exchange of Yakko and Wakko wanting Taz to "do that funny thing that you do." This, unfortunately, messed up the punchline at the end where Taz actually does "do the funny thing".
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When the firefighters lead Slappy out of the smoking house, her cuckoo clock says three o'clock, but the bird only chirps twice.
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Wakko drinks Grogg in the episode.
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Just before the sickbay scene ends, when Korn's ship attacks the Star Truck, the doctor's uniform tunic is seen as gold instead of blue.
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Freakazoid makes a cameo in this episode.
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When shown on Nickelodeon, the shot of Yakko & Wakko greeting Hello Nurse as a "femme fatale nurse" was cut out. The "Give me the bird!"/"We can't, this is a family show" exchange was also cut.
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Wile E. Coyote makes a cameo in this episode.
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The nerd at the beginning of the episode comments on the closed-captioning mistakening the "pay or play contracts" line in the theme song as "pay for play contracts." Usually the captions spell that line correctly, but for this episode, the captioning deliberately spelled it as "We have pay for play contracts" to make the gag funnier.
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Look Hard: When Yakko and Dot are looking at all their fan mail, Wakko asks, "Isn't any of it for me?" Before Ralph pours the bag into his lap, some of the letters on the floor have "Wakko" written on them.
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Animaniac Cameos: Runt, Yakko, Pinky, Brain, Slappy, Skippy, Hello Nurse, Buttons, Mindy and Rita.
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Many of the buildings that collapse during the song are actual depictions of Los Angeles skyscrapers (Bank Of America Building and Library Tower).