The name on the Instant Pestering screen is ZorakFan3271.
One of the pop-ups at the end is advertising "Assisted Living Dracula," the movie that Shake watches in Bus of the Undead.
When the www.yzzerdd shows off the Instant Pestering service to Frylock, the message in the window (supposedly from Shake or Meatwad) says, "Are you home yet?"
At the very end of the episode, Shake clicks on a pop-up ad and the episode ends. The ad he clicks on says, "Congratulations! You have just finished another episode! Click here for the super end credits!"
Shake: Well, I got rid of my teeth at a young age, because... I'm straight! Teeth are for gay people! That's... why fairies come and get 'em!
Shake: Plaque is a figment of the liberal media and the dental industry to scare you into buying useless appliances and pastes. Now, I've heard the arguments on both sides, and there is nothing to convince me of the need to brush your teeth.
Frylock: I wanna speak to your supervisor!
www.yzzerdd: All right, hang on a sec, I'll be right back... (Starts sparkling, then puts on a black beard and mustache on his face, then stops sparkling) I'm the supervisor. What seems to be the problem?
Frylock: Wha- YOU'RE THE SAME DAMN GUY! YOU JUST PUT ON ANOTHER BEARD AND MUSTACHE! (Short pause)
www.yzzerdd: It's only $44.95 a month. That's pennies a day.
Frylock: Look, I didn't sign up for this crap. It was my roommate's doing.
www.yzzerdd: Surely this convenience entices you! Pornography and online gaming at hundreds of times the speed of your normal advertising service provider! It's so easy to use, and the surgery to implant it in the base of your skull is so painless that its no wonder I'm number one!
Frylock: Why is my door locked?
Shake: I don't know, we've never been back there. Hey is that your room? Hey when did you start living here? Hey, we're roomies!
www.yzzerdd.com is an actual website that was obviously created for the show. It's a flash movie of the www.yzzerdd and it features every pop-up from the show.
A pop-up ad in the living room about winning a new house shows Brak's house from another [adult swim] show, The Brak Show.
The fanfare tune which is played when the www.yzzerdd appears is taken from the the original BBC series The Hitchhiker's Guide to the Galaxy; the tune is played when Slartibartfast appears in a transmission.
The Run of the Mill search engine is designed to look like the famous Google.com engine.
America Online (AOL)
The www.yzzerdd: It's so easy to use, and the surgery to implant it in the base of your skull is so painless, it's no wonder I'm number one!
This is a parody of the longtime AOL catchphrase, "So easy to use, no wonder it's number one!" AOL is owned by AOL Time Warner, which is Cartoon Network's parent company.