The opening "Spacecataz" sequence, the Mooninites and Plutonians are talking smack to each other. When the Plutonians fail to "flip the bird" back to the Mooninites, they decide to "moon" the Mooninites. The Mooninites retaliate by giving the Plutonians a "full frontal."
The main episode opens up with Frylock boring his roommates with his lecture on improving computer technology faced with microscopic limitation. When Frylock ultimately reveals his shrink ray, Shake and Meatwad go crazy with it until Frylock aprehends the ray from Master Shake. When Frylock tries to open up his roommates to the possibilities of the shrink ray, Shake and Meatwad can only think of personal gain, such as a pool or overgrown hot dog. When Frylock shrinks the computer chip, Meatwad mistakes it for a potato chip and eats it.
Frylock, in an attempt to get his computer chip back, makes Meatwad drink to clean out Meatwad's systems. Jealous of the attention Meatwad has received, Shake drinks the second drink, which causes him to throw up...a lot. Shake goes to lie down while Meatwad enjoys snacking on Shake's throw up. Frylock reveals his intentions with Meatwad, but Meatwad reveals that he cannot excrete matter, comparing his body to the Thunderdome. Meatwad gets Frylock to say "poop" and gets ecstatic about it, while Shake is still upset from the drink.
Frylock's plan, which is modified from Meatwad's plan, is to shrink himself and have Shake inject Frylock into Meatwad's body. Shake, however, starts to shrink Meatwad instead. After Shake shrinks Frylock, Shake leaves the house and enlarges a pool.
In the next scene, a shrunken Carl is thrown into a setting with a miniature Frylock. Shake, playing with Carl's insecurities, has Carl fighting Frylock. Meanwhile, Shake is messing with the shrink ray on Carl and Frylock. Frylock gets Carl to cooperate under the condition that Frylock will help Carl with enlarging Carl's manhood. Shake makes a "hail storm" of Orange Soda on his two friends, which Frylock reacts with his own rays. Shake decides to "compare rays" and shrinks Frylock to a microscopic size. Shake then throws Meatwad into the battlefield with Carl.
A sleeping Master Shake, next to an enlarged hot dog weenie, is woken up by Carl, Meatwad, and Frylock, who are now small enough that they have crawled into Shake's brain, or lack thereof. Frylock gets Shake to beat himself up with a baseball bat, then MEatwad gets Shake to cut off his own tongue with a chainsaw. Frylock gets Shake to increase Meatwad with the Shrink Ray, but Meatwad does not return the favor, instead finding amusement in the overgrown hot dog.
Meatwad is seen in the next scene asleep on the recliner. Woken up by Frylock, Meatwad offers Frylock some of the overgrown hot dog. In Frylock's room, Carl is getting read to increase his "package." Frylock reveal to Meatwad that Carl and Frylock had to blow out one of Shake's eyeballs to get out. After Carl "enhances" himself, items that were originally shrunk start to grow back, like the computer chip. Frylock destroys the shrink ray after seeing all the mayhem it has caused, and crabs start to pop out of Carl's pants. Carl tells the others that if the crabs get close to hit them with "the shampoo."