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Lana goes into labor as the rest of the former members of ISIS prepare to flee San Marcos. Amidst the chaos of the evacuation, the truth comes out about the cocaine's true origins.
Once Gustavo Calderon learns that Cherlene is among his captives, the ISIS gang quickly goes from unwanted pests to honored guests and are invited to stay at the palace. As they settle in, things get dicey when Kreiger learns he is not alone, the maid Archer beds is anything but that and what sounded like fireworks go from pop pop to ka-boom.moreless
Cyril, Ray and Archer successfully sneak back into the United States in their stolen plane laden with cocaine only to run into some ex-military weapons dealers running guns to South America.
As Archer, Ray, and Cyril attempt to leave Colombia and head back home, Lana, Pam and Cherlene try to cheer Malory up with an impromptu spa day.
Archer's secret mission to Columbia becomes a not-so-secret mission when he gets drunk.
Archer finds hiring Kenny Loggins for Lana's surprise baby shower is proving to be more difficult than he anticipated.
Cherlene, who refuses to fly, has a gig in Texas so Archer procures a bus and a blocker car, a la Smokey and the Bandit, to get her there in time.
Drastic measures are chosen for Pam and Cheryl which proves to be too much for Ron Cadillac and everything must be kept hidden when a nosy FBI agent comes sniffing around.
The former ISIS members must deal with the Yakuza after Pam swindles them out of a million dollars worth of amphetamines.
The former ISIS members try to put some of their espionage skills to use when they undertake a risky high stakes Miami mission.
The fifth season begins with ISIS coming under attack and coping with the loss of one of its longtime members. And then things just get really crazy.