Krieger does some tests on Archer's cancer drugs and concludes that they are primarily made of sugar. Archer quickly decides to hunt down whomever is selling the counterfeit drugs. Lana tags along for the "rampage."
Meanwhile, at ISIS headquarters, Krieger reveals to Cyril that he grew up in Brazil. With some minor investigating, the employees at ISIS find out that Krieger is one of the boys from Brazil - a genetic clone of Adolf Hitler. Malory already is aware of this, and doesn't seem to have a problem with keeping Krieger's job intact.
On his rampage, Archer goes after the Irish mafia, having discovered that they are behind the fake drugs. On the crazy journey, he finds some actual chemo drugs and makes the odd decision to take them, but they make him very sick. He balances out the chemo side effects by smoking marijuana and thinking of Ruth, an elderly woman also combating breast cancer with fake drugs.
When Archer finds the boss of the whole operation, he has been told that Ruth died. She would start her day by watching Regis to cheer herself up; Archer asks the boss if he saw Regis that morning, and then kills him.
The finale of Archer's rampage reveals that he has been making a movie of his operation called "Terms of Enrampagement." He has been making his ISIS coworkers watch it every week for the past twelve weeks; Archer's cancer is also in remission.