In one of the later episodes - season 2 finale maybe? - GM and Maeby are at the Dangerous Cousins American remake protest, I think, or maybe it happened in their room? Anyway, Maeby says that they had to make them not biological cousins for the American version because it was too controversial. I wonder if that's a bit of self reference? It's odd that they threw that line about the test tube into one of Lucille's rantings right in the beginning of the show, maybe had the narrator mention it once or twice, then leave it alone until the very end of the series. Did the network force them to alter the pilot because they were afraid of the controversy? Did they want to save the adoption angle for the end, or was that tacked on too after they got canceled?
This show tends to do a metric ton of foreshadowing with their planned plot twists, I'm not sure if they were finishing planned storylines or just throwing it together. Thanks.