According to Stan Berkowitz: "Chemistry" is a metaphor for marriage, specifically, the way people change once you've been intimate with them for a while. Since many of you reading this are too young to relate to being married, trying looking at it the other way: since you know your parents intimately, try going to work with them some time; you'll see an entirely different person
"Chemistry" was exaggerated, of course, but sometimes you have to do that to make your point. One side note: in the first draft, there was no mention of pheromones; Bruce fell for his fiancée because she fit in with him perfectly; she did whatever he wanted her to do, and never gave him any problems. But real relationships aren't that easy, nor should they be; if you get whatever you want all the time, you don't grow, and (in the real world, anyway) you're pretty much guaranteed to have a mate who won't be there very long.