There is no doubt that Aunt Clara is from Endora's side of the family and, as mentioned, Serena is from Maurice's. Whenever Maurice sees Aunt Clara, he always kisses her hand and tells her how beautiful and amazing she looks which he wouldn't do if she was one of his relatives. Endora calls Clara by her first name, she doesn't call her Aunt Clara, so I think they are sisters. When the baby is born, Clara says she is now a great aunt rather than a great, great aunt, so that means that she is Samantha's aunt from the first generation which, in my opinion, makes her Endora's sister.
As has been stated, Serena says a couple of times that she is from Maurice's side of the family but exactly how, we are not sure. Maurice is British, Serena is American so that probably means she is the daughter of his sister or brother who emigrated to America as Endora is also clearly British.
The whole thing is pretty confusing but, as you have all said, most of the familial relationships were never explained properly on the show.
Edited on 01/06/2011 4:09am