Blade invades Amaurot, the City of Vampires and headquarters of Existence, while cutting his way through anything that stands between him and Deacon Frost. Meanwhile, Van Helsing and Kikyo Mikage engage in fierce battles of their own.
While in captivity and pushed to his limits, Blade struggles to regain control of himself as his allies attempt a daring rescue. But a price will be paid for their efforts against Frost and his vampire forces because not everyone will make it out alive...
A captured Blade is taken to the Existence research lab known as 'The Factory’ to be experimented on by Deacon Frost who divulges his own awful ambitions. Meanwhile, Makoto puts everything on the line to rescue the Daywalker.
In the jungles of Vietnam, Blade is attacked by a band of vampire ninjas. Rescued by an American Soldier, Blade learns of a secret U.S. Military initiative called the "V Plan". But before Blade can unravel its secrets, he is confronted by a mysterious attacker.
Blade arrives in Madripoor and is instantly attacked by a local gang when an old acquaintance, Wolverine, appears. Lucius Isaac who controls this local gang is also a servant from the pureblood vampire High Council whose aim is to destroy Existence.
In his quest for Frost, Blade travels to the Island of Sumatra in Indonesia and launches an attack on a silver mine operated by Existence. There Blade and Makoto come into conflict with a witchdoctor who claims to have a cure for vampirism.
Sakomizu, a middle-aged police detective in Osaka, is troubled by a recent series of missing Southeast Asian women. After he meets up with Blade, they discover that the chief of police is helping to provide local vampires with human blood.