Not great, not completely horrible. It seems to me that the scientific stuff doesn't reach the level of other shows, and all of it (as well as the rest of the show) was very rushed and had a feeling that it didn't know where it was going. I would definitely say that, with the exception of the two leads, the rest of the show should be recast. I suspect that a lot of characters will be dropped anyway, as tends to happen in shows like this. Three kooky assistants is one or two too many.
And come on. The Jeffersonian? That's just lame. There was also a big goof right in the very first shot of the show. A plane flys in front of the Capitol building, and there's a caption that says "Dulles International Airport: Washington DC." Anyone who lives in this area knows that even if you were on top of the control tower at Dulles, you won't be able to see half way to the city. Interesting trade-off. Flights from Guatemala wouldn't fly into Reagan National, but the city isn't visible from Dulles.
Nit-picking aside, David Borneaz is definitely the highlight of the show, and Emily Deschanel grew on me as the show went on.
Decent, but it had better improve over the next couple episodes or I won't watch anymore.