Humour and pseudo science are the bread and butter of this show.
Bones is your average run of the mill Hollywood genius who has written several books by the age of thirty and has mastered all human knowledge except social interaction. She has surrounded herself with other loyal geniuses who form her dysfunctional genius league. Luckily there is Booth, the down to Earth FBI agent, to provide a comedic counterweight.
Bones' particular field is identifying the bones of murder-victims to establish their identities, time and method of death, etc. It's fairly impressive if made slightly ridiculous by the fact they threw in a giant holographic projector to display their theories with. Other then that it is a field you will be largely unfamiliar with, so if you like science talk it will certainly hold your attention.
Bones will of course only consent to help the FBI if she gets to visit the crime scenes, which brings her and Booth into nice situations and decomposed bodies to exchange quips over.
Voilà, you have yourself a crime show.