While Miller publishes a story that threatens to destroy Kane, he battles to stay on top, but is concerned over Doyle's alliance with Kitty.
As the city's emergency managers prepare to take over, Kane's enemies threaten to unseat him.
In order to keep his grip on Chicago, Kane finds he has no choice but to work with Alderman Ross.
Now that Kane's treatment seems to have worked, he must regain control of Chicago.
With riots breaking out at the housing project, Kane seeks treatment at an alternative clinic, but his past comes back to haunt him.
While the symptoms of his disease leave him unable to differentiate between reality and hallucinations, his hold over the City Council is threatened by his anti-corruption stance.
While his wife and daughter reject his efforts to reconnect, Kane streamlines his political staff.
Kane decides to redevelop a housing project, to get closer to Mona.
Needing to find a replacement for Stone, Kane hires an ambitious newcomer to the political scene and entices his adversary's aide.
Mayor Thomas Kane attempts to ignore the symptoms and hallucinations of his disease and concentrate on new enhancements to the terminals at Chicago airport.