Sam (Ted Danson), a former pitcher for the Boston Red Sox, owns and runs Cheers, a cozy bar in Boston. Somewhat snobby, beautiful and intelligent Diane (Shelley Long) -- forced to become a waitress when her fiance jilts her -- constantly bickers with Sam. Eventually, they fall in love.
For years the main characters have remained in the story. Others came and went sometimes for short periods and sometimes for many episodes. They helped to make the story more exciting.
Some of the main characters were Carla Lozupone Tortelli LeBec, Hilary Norman "Norm" Peterson, Sam "Mayday" Malone, Dr. Lilith Sternin-Crane, Diane Chambers, Rebecca Howe, Ernie "Coach" Pantusso, Clifford C "Cliff" Clavin, Jr, Woodrow Tiberius "Woody" Boyd and Dr Frasier W Crane.
Each episode is a story on its own but it forms part of the whole story.