Cliff: Normy, come on, will you? The buddy of ours is on the ledge, he's about to jump to his death. Let's go!
Norm: Jeez, you're right, I'd better go move my car.
This episode was filmed on October 12, 1992.
The events of this two parter are mentioned in one early episode of Frasier, when he tells to his father an endearing story from his past, in order to get closer to him.
Bebe Neuwirth temporarily leaves the show in this episode to work on Broadway. She returns in "Is There A Doctor In The Howe?" later on in the season.
The episode title is a pun of The Boy in the Plastic Bubble, the 1976 TV-movie which starred John Travolta as a young man with a defficient immune system which forced him to live in a sterile environment.
Lillith: I'm going to live in the ecopod.
The Ecopod is a reference to the Biosphere II: in which several pseudoscientists/cultists lived in what was hoped to be a self-sufficient replica of the Earth. The experiment was a failure.