Personally, I thought Mandy Patinkin was fantastic in the show, but I believe it DID manage to hold it's own without him, possibly better than Criminal Minds has managed to do, although, there's still time for Criminal Minds. Mandy is such an excellent actor that it's a pity that he has left two shows in which he had such major roles.
Do others think that Chicago Hope managed to continue and be excellent without Mandy or did it drop considerably in your estimation?

