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Dr. Yeats becomes Jack McNeil's superviser as a punishment for disregarding his patient's wishes.
Dr. Cacaci's son Nathan was previously played by Haley Joel Osment in "Memento Mori" during season 4.
Dr. Rose Webber is introduced as Aaron's new Attending Physician in the psychiatry program replacing Dr. Franks. However, Dr. Franks had been identified as the Chief Resident of the program.
Dr. Shutt's patient Jacob would not be clean-shaven as an Hassidic Jew.
Goof: When Dr. Corcoran is brought into the ER, the paramedic tells Dr. Grad that the patient is only responsive to deep pain. But then she pipes up with a comment, which would not be possible if she was only responsive to deep pain.
In season 4, Wilkes tells Watters that he "doesn't do guns" during the episode "Psychodrama". Apparently the intervening traumas have changed his mind.
The poisonous that is released is sarin. The episode is a play on the word serendipity (good luck, destiny).
This is the last appearance of Aaron's boss, Dr. Frank.
Aaron is 42 year old.
Ariel Felix is credited in a recurring role as an anesthesiologist in many other episodes.
Diane's baby is born. It is a girl that they name Emily.
Dr. Austin's daughter Sara is 10 years old.
This is the third time this season that doctors traveled to a conference.
In the previous episode, Dr. Kronk had broken his hand, and was in a cast up to his elbow. Wilkes took him off the surgical schedule.
Diane Grad is 35, and was born in 1962.
Dr. Catera ran varsity track for three years at Brown.
This is the episode that Dr. Shutt decides to step down as the chief of neurosurgery.
Jack McNeil had retired and was living in Wyoming when Phillip recruited him to come to Chicago Hope. So why did he have a cabin outside of Chicago?
Lisa Catera, who was so named because of a Cadillac commercial ("lease a Catera"), is shown in this episode driving a Volvo.
This is the episode that Dr. Shutt decides tho switch specialties to psychiatry.