This show is unlike anything else on television right now. It not only combines genres, but redefines it - action/adventure, romance, comedy, and drama, are all combined in the right proportions, with a few significant modifications (eg. the concept of the "nerd" becoming an upper echelon spy). Not to mention the fact that it features a FANTASTIC soundtrack.
Chuck (Zachary Levi) epitomizes the typical Josh Schwartz show's resident nerd - armed with an arsenal of obscure references, decked out in (for lack of a better phrase) geek chic, and just waiting for the right girl to come along (see also: Adam Brody, Penn Badgley). In fact, Chuck beats out Lee Pace's Ned (Pushing Daisies) in terms of likeability - by no means an easy feat. Definitely a 10 in my book.