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While on their separate vacations, each member of the BAU receives a clue from a psychopathic killer who challenges them to save his next victim.
The team travels to New Jersey where several people have been poisoned in Beachwood, one fatally, with LSD 10-20 times more potent than a common dose taken recreationally.
Elle, along with many others, is held hostage on a train in Texas by a paranoid schizophrenic who is convinced that the U.S. government is monitoring him. Hotchner and Gideon are forced to play into the man's fantasy to save the people he has taken hostage.
When an undercover cop in Baltimore involved in a mob investigation goes missing, the BAU believes a serial killer rather than organized crime has something to do with his disappearance. The probe leads to several unsolved missing persons cases.