After a suspected serial killer wakes up from a coma, the BAU reopens the case and uses brain fingerprinting to determine if he really doesn't remember the crimes that had been committed four years earlier in Roanoke, Virginia.
With Gideon missing, and Hotch and Prentiss off the team, the BAU investigates one of its most difficult cases yet as the remaining agents track a serial killer in Milwaukee who abducts women in public places by using his son as bait.
Rossi goes to Indianapolis to continue his investigation into the two unsolved murders that have plagued him for 20 years, and he is joined by Prentiss, JJ, and Morgan when they learn about the case. Meanwhile, Hotchner and Reid interview a death-row inmate in a Connecticut prison.
In the first of a two-part story, the BAU pursues a cannibalistic serial killer in Bridgewater, Florida, that leads Morgan to a crisis in his faith. Garcia believes she has met her dream man, but her first date with him doesn't go exactly as she had expected.
The BAU travels to Oregon to assist local authorities in investigating the disappearances of people who are new to the city and have no strong social ties in Portland. All the clues lead to a psychiatrist who may be using his patients' worst fears to murder them.
After the contents of a self-storage unit purchased at an auction take the BAU to Philadelphia to investigate a series of murders, the local agent becomes the center of the case. To catch the killer, the team must profile the items inside the unit.
The team investigates a serial killer who is targeting women at a small Arizona college in Flagstaff. The BAU shuts down the campus, creates a detailed profile of the unsub, and arrests a suspect. However, the team members begin to have doubts about themselves after another woman is killed while the suspect is in custody.moreless
The new sheriff in Fredericksburg, Virginia, requests the BAU's assistance in the investigation of a series of mutilation murders that appear to mimic similar crimes that had occurred over two decades earlier.
The BAU travels to Dallas to assist in the search for a murderer who scares his victims with "missing" flyers that display the soon-to-be victims' photos. Also, SSA David Rossi returns to the BAU from retirement.
The team members try to identify a stalker before he can attack a woman who is being stalked in Silver Spring, Maryland. Meanwhile, Hotch and Rossi are called as consultants on a possible battered woman syndrome murder case in Boston.
The BAU is called to Montana to investigate the case of three kidnapped and murdered women. When another woman disappears, the search leads to a man who has apparently assumed the identity of his partner who committed suicide.