Nate Haskell, the Dick and Jane killer, continues to taunt CSI, this time by sending a video to the family of Vivian Tinsdale, one of his chosen brides. As the team investigates, they realize that Haskell was blackmailing Vivian's father. Apparently, Vivian revealed that she'd been sexually abused by her father. Her father killed himself rather than have that part of his relationship with his daughter revealed.
Meanwhile, body parts are found in a barn, and it's difficult to identify whom they belong to. They appear to be a woman and a man, but the woman's body is missing the head and only a man's hands are found. The man is eventually identified as a plastic surgeon, and his nurse, the woman.
The team finds out that Haskell visited the doctor's office, got a new face, and then killed the doctor and nurse. Vivian's body is also found. Haskell has escaped and is headed to L.A.