Nick and Sara are called on a missing persons case. Dwayne Hicks has reported his wife missing, but then CSI find out that her house is missing as well. The house itself is a point of contention for Dwayne and his siblings, all of whom are involved in a bitter feud over who will inherit it.
The house is found somewhere in the hills, along with multiple dead bodies in and around the building. Youngest daughter Marla convinced construction worker Dennis Hastings to steal the house so that the family wouldn't have to fight over it any more. However, Marla didn't realize that the body hidden within the walls was her own biological father, and that the man whom she'd known as her father murdered her real father many years ago, hiding the body in the house. The culprit, Walter Hicks, murdered Marla's father for having an affair with Mrs. Hicks. Walter did the same thing with Fred Blanchard, another one of Mrs. Hicks' boyfriends.