Andrew: "You're the one with the problem, all right. You're the one who's acting she's running for mayor of Stepford."
Bree Van De Kamp is described as "the perfect mother." Her son then makes a remark about Stepford. This is most likely a reference to the movie(s), The Stepford Wives (1975) (starring Katharine Ross) or the recent remake, The Stepford Wives (2004) (starring Nicole Kidman). The women living in the town of Stepford are too perfect à la Bree, and turn out to be robots.