Dexter appears naked for the first time in this episode.
Dexter's alarm clock has Einstein on it.
One of the questions that Mandark answers is "What is the name of Neptune's moon?"; Neptune has eight moons.
Mandark says to Dexter "Some kid told me you have a laboratory." Even though Dexter's friend Douglas knows, isn't his laboratory supposed to be secret?
Mandark says Thomas Jefferson wrote the Bill of Rights, but James Madison did that.
Mandark: The answer is hydrogen.
Mr. Luzinski: Yes, that is the correct answer to the question I was about to ask.
Mandark: Yes, Dexter, I can read your thoughts, and I am smarter than you.
This episode is unlockable in the video game, CN Racing.
Mandark first gets his crush on Dexter's sister DeeDee in this episode.
In the beginning of the episode, Dexter:
1: Wakes up with a grin on his face.
2: Dances while taking a shower.
3: Waits for the bus in a good mood with the sun shining.
and 4: Is greeted by all the teachers when he greets them.
After his lab is shutdown because Mandark threatens it, Dexter:
1: Is depressed while taking a shower.
2: Is gloomy when waiting for the bus in the rain.
and 3: Is ignored when greeting the teachers and then is trampled by peers and teachers when Mandark shows up.
Mandark's last name is "Astronomenoff."
This is the first appearance of Mandark and Mr. Luzinski, who also becomes known as Mr. Phillips.
School: Huber Elementary
The school Dexter goes to is called Huber Elementary. This is a reference to Larry Huber, the executive producer of Dexter's Laboratory.
The big, black ball in Mandark's lab is a reference to the Death Star from Star Wars.
Computer: Dexter? What are you doing, Dexter?
This scene where Dexter must shut down his computer is taken from 2001: A Space Odyssey.