I had always assumed that Echo did kill her. Although after tonight's episode and the last few for that matter it wouldn't make sense for Echo to kill her. Dewitt turned out to be good, on Echo's side, she helped in every way possible to destroy Rossum and her moral constitution really showed in all of her dialogue. Why would Echo be so angry at her in the future? Well there could be something we don't know. Ater all we're missing 9 years worth of story, hard to say what sort of falling out could have occurred between Dewitt and Echo. Or maybe Caroline started having more influence in Echo's mind, so she came to blame Dewitt for the condition of the world, since Dewitt is the one who originally handed Topher's plans over to Rossum? Hopefully Epitaph 2 will clear this up.
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