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Doogie and his father visit an operating theater in Honduras, where Doogie finds a surgeon's professionalism to be lacking.
Doogie tries to help an elderlypatient whose memory is failing him. Meanwhile, Vinnie has an introspective video experience.
Doogie's advice that Vinnie accept his shortness and Wanda be open to her father's girlfriend goes over like a lead balloon.
A Palm Springs vacation sees Doogie considering accepting a trauma surgery fellowship and Vinnie being jealous of Janine.
Janine's choice of a fashion career over college angers her parents.
Doogie ponders what his medical specialty should be and finds out his father's practice has offered someone else a job there.
An outing for Curly's 30th birthday leads to Doogie seeing her in a completely different light.
Doogie gets the opportunity to see what it means to be a grown man, when he discovers his girl friend has a four-year old son and Dr. Ron Welch asks him to be his best man. Doogie starts to realize being a genius doesn't have to mean doing everything before people normally do it. He can do stuff in his own time, whether that be early, on-time, or even later than others.moreless
Doogie is shadowed by a self-centered actor looking to give more realism to his performance on a TV show.
Vinnie's sure that even working in a busy ER can't prepare Doogie for work in a burger joint.
The Eastman staff is on edge for fear the examination of a mummy will bring about a curse. Meanwhile, Doogie ponders on how much modern medicine still can't accomplish.
Katherine and Ray have their pasts come back as a temptation, which creates problems for Doogie in how to deal with his Mother's first love and Ray's old gang. A high intelligence doesn't always have the solution, especially for emotional issues; sometimes someone only needs the maturity that comes from experience.moreless
A spat with Vinnie allows Doogie to learn about the power of laughter when he runs into a patient with serious kidney disease and a boss who works for stooges.
Vinnie says Doogie is a bigger pig than him after Doogie talks up a girl but won't ask her out to a New Year Eve Concert. Doogie gets to evaluate Vinnie's opinion first hand after the girl decides to get plastic surgery and Doogie see the end results in advance of the surgery. Meanwhile, Ray's youth councilor turns out to have two major secrets that can cost him his life different ways.moreless
While home sick, Doogie finds remaining friends with Wanda is more difficult than he imagined when she calls for relationship advice.
Katherine and David want Doogie to start paying for his room and board, but at the same time continue to treat him like a "pre-adult." Meanwhile, Curly doesn't understand why her father is resistant to getting a pacemaker.
Doogie and Vinnie have a series of negative events leading them both to view aspects of their lives to be over. With Wanda's birthday the next day, Vinnie suggests a 2,000 mile road trip to Chicago. The leads Doogie and Vinnie to their own adventures and epiphanies after their car breaks down. Doogie meets a girl who like him is a genesis. Meanwhile Vinnie meets a man whose views on careers brings out the artistic side of Vinnie.moreless
Doogie and Vinnie work on a screenplay, where Doogie is a Civil War doctor. Meanwhile Doogie learns an important lesson at the hospital that the old pedestrian ways has advantages over a new Top Gun method.
Wanda returns to L.A. when a piece of hers is chosen for a gallery show, but Doogie's taken aback by how much she's changed in so short a time.
When Janine seems to be distancing herself from Vinnie, he struggles with his desire for a classmate.
The parents of a disabled child stymie Doogie, when they choose their religion and community beliefs over allowing him to walk through an operation. Meanwhile Janine comes up with a solution to her father's rejection of Vinnie; they're going to follow the example of Doogie's parents. She proposes they elope to Vinnie.moreless
Doogie and Vinnie's place is raucous and fun-filled, but Doogie really just needs someone to talk to.
Doogie struggles making a decision on how to care for a young patient.