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Despite the fact that there are two old ladies for Josh to make out with, he's only shown making out with the grey-haired one on-screen.
After Brian and Steve-O get the cigarette burn marks together, Brian says that him and Steve-O will now have matching burn marks for life. A cigarette is not nearly hot enough to give a burn mark for life unless it was extremely above normal temperature.
Josh's personal procedure was the only one in all of the show's short history that didn't actually require getting over any fear whatsoever. His fear was being shy, however the girl came to him.
Unless David had unshown tutoring, he managed to balance the glass on the dime after just seeing Steve-O do the trick once.
This is the only show where Steve-O walks out on a patient, he eventually comes back though.
Jesse, one of the patients, lost 50 pounds of fat on the Richard Simmons Workout.
Jordan was the only one to back out of group therapy in the history of the show.
Jace is the only patient ever that was first met at his job.