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Eddie's daughter is a history major at Ithica State College.
Brent Spiner becomes the second of the Starship Enterprise crew to guest star on the show after Gates McFadden's turn in The Book, the Thief, Her Boss and His Lover, Spiner played Lt.Cmdr Data for seven seasons on Star Trek TNG and four spin-off feature films.
Melora Walters appeared in two late 1990s movies directed by P.T Anderson – Boogie Nights and Magnolia.
Madge Sinclair sadly died of leukemia shortly after this episode was aired in December '95.
Barbara Alyn Woods guest starred earlier in the show's run, but as a different character named 'Linda,' in Episode 3.21 - It Came From Beneath the Sink
Molly Hagan appeared as a guest star in a season three episode of Six Feet Under, another HBO show (ep 3.8).
Michael McKean married Annette O' Toole in 1999.
David Graf appeared as Tom Arnold in the infamous Roseanne: An Unauthorized Biography TV movie in 1994; Roseanne was played by Denny Dillon. Also, Cattrall and Graf appeared together in the 1st Police Academy movie.
Linda True reprised her role as Rachel in two other episodes - 108 ("Little Orphan Eddie") & 110 ("The Weekend at the College").
John Landis appears as a guest star for the second time (after ep 20. Futile Attraction) as the therapist Herb.
Jake Steinfeld is "Body by Jake", the popular fitness guru.
Jake Steinfeld, who plays Mack, appeared in the John Landis' films Into The Night (1985) and Coming to America (1988).
Chelsea Field guests in this episode as Allison, Field's husband Scott Bakula guest starred a year later in 'The Taking of Pablum 123' episode.
Both Paul Dooley and Dion Anderson appeared as Cardassians on Star Trek: Deep Space Nine; Anderson playing Zolan in 'Cardassians' (in ep 2.5) while Dooley had a recurring role as Enabran Tain (in eps 2.22 3.20,3.21 and 5.14).
Roxanne Hart starred on "Chicago Hope," and the short lived "The Road Home." 2004 Credits: "The House" episode of "Cold Case," and "Identity Crisis" episode of "Strong Medicine."
Matthew Perry who plays a memorably slimy Alex in this episode went on to find greater fame as "Chandler Bing" in Bright-Crane-Kauffman's other, more celebrated, show "Friends." Perry also starred in 1987's short-lived "Second Chance" (and it's revamped, renamed verision "Boys Will be Boys"), the short lived 1990 show "Sydney" (Craig Bierko also starred on this show, and apparently, was asked to play "Chandler" in "Friends"), and the short lived 1993 show titled "Home Free."
Perry directed and acted in the November 2004 episode "My Unicorn" of "Scrubs."
Jessica Tuck, "Skylar" in this episode, had a supporting role in the 2002 Steven Shainberg S&M comedy Secretary. Tuck starred in "The Last Frontier," "One Life to Live" (1988-1992) and currently stars in "Judging Amy."
Jenifer Lewis starred in "Courthouse," "The PJs," and currently stars in "Strong Medicine."
Della Reese starred in "Touched by an Angel" and "Chico and the Man" (among other shows).
Reni Santoni starred in several failed shows: "Manimal," "Sanchez of Bel Air" and in "Owen Marshall, Counselor At Law" (1973-1974). Santoni also guest starred as "Judge Thomas Agajanian" on at least five episodes of "Murder One."