The title card for "In Space, No One Can Hear You Rock" displays "In Space, No One Can Here You Rock".
X-2: (about new weapon) Behold! The Sax-Oblivion!
Queen: (indignant) That's not the name we agreed on!
X-2: (sheepishly) I know, but it's just so perfect!
DD: (to Dave Mustaine) If you're on stage and you don't know what city you're in, just yell "Thank you, Detroit!" There's a 47% chance you'll be right.
X-2: (about Megadeth) It's too loud!
DD: You're too old!
Queen: I see you're skeptical, Commander. So, I'll let you do the one thing you've always wanted to do.
X-2: (eagerly) Drive a Zamboni?!
Centurion: If we're going clothes shopping, Commander, we would like some new jeans.
X-2: But you don't have legs!
Centurion: All the more reason to wear jeans, sir.
Queen: Why are the Centurions wearing those awful pants?
Centurion: (to X-2) I told you these pants were ugly!
Dave Mustaine is billed as "Special Guest Star."
David Mustaine and Megadeth perform the song "Back in the Day" from their 2004 album "The System Has Failed".