Luke Duke while the General needs water gets some water that has bad chemicals in it and drinks it. It turns him into a real mean person. He badmouths Bo, Daisy, Uncle Jesse, The Duke Farm and the whole Hazzard police department. He hits on every woman he meets. He ends up leaving the Duke farm and buying the General Lee after criminals ask him to help them rob a bank. During the time before the bank robbery the rest of the Dukes find out about the chemicals. He is on his way to rob the bank followed by Jesse, Daisy, and Bo in Daisy's Jeep. They get a flat tire when Enos comes by Bo tells him of the plan to rob the bank. They head towards Hazzard to intercept before they rob the bank. They then see the criminals going the other way stop them. Enos holds them in his patrol car while Bo tries to stop Luke. Luke pulls a gun on Bo. Bo says you don't want to hurt me. Kicks away the gun from Luke and jumps on him. They fall down the hill where Luke continues to fight with Bo mostly one-sided. Luke is about to hit Bo when the chemicals wear off. He ends up making up with Bo and apologizing to everyone he bad-mouthed. This was a great episode because it was totally out of character for a Duke to act like that.
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