Watson: You're not the same person I met a year and a half ago. You're--
Holmes: Good to you? Yeah. For the most part. I consider you to be... exceptional. So I make an exceptional effort to accommodate you. But you must accept that, for as long as you choose to be in my life, there will occasionally be fallout from my behavior. That must be a part of our understanding.
Watson: No one can accept something like that forever.
Holmes: To thine own self, Watson.