Holmes: I've lived most of my life with the firm conviction that romantic love is a delusion. It's a futile hedge against the existential terror that is our own singularity. Then I met someone who calls herself Irene Adler, and that forced me to reexamine those convictions. She, of course, turned out to be a criminal.
Watson: Never really discussed how that made you feel.
Holmes: I feel liberated. I am, now and forever, post-love. And, as such, I'm free to pursue a life of meaning.