Eli's Theory is a family comedy-drama about a gifted boy and his adventures in an accelerated education classroom. Young Eli (Matt Weinberg) is a computer genius, and a stressed-out professor (Edward Asner) recognizes his talents, placing him in his class for gifted students. Eli thinks that he is smarter than most people, including his garbage collecting father (Tom Verica), who Eli constantly corrects throughout the series. The smart boy soon meets his classmate Angela (Teresa Couch), and the two adolescents start an instant rivalry of wits, which almost puts their professor in retirement. One day, Eli decides to pit the boys against the girls in a classroom debate. The genius finally gets the opportunity to put Angela in her place, once and for all, after she misses a question. Things get complicated for the boy after Eli intentionally gives his professor the wrong answer, when he suddenly realizes that he likes his arch rival.